Volume 5, Issue 1, Pp8-14, 2022COMPARISON OF THE DIAGNOSTIC PERFORMANCE OF 2DAND 3D MR IMAGES IN STAGING AND HISTOPATHOLOGYFINDINGS OF LOCALLY ADVANCED CERVICAL CANCER Guo-Jie Wang1#, Le-Wei Yang2#, Shi-Rui Yang3#, Bin Zhou4, Run-Gen Zhan5, Ya-Li Zhang6, Yong-Jun Peng5*, Jie Zhang5* 1.Department of Radiology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China 2.Department of Abdominal Oncology, The Cancer Center of The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, China 3.Department of Nuclear Medicine, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China 4.Department of Pathology, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China 5.Department of Radiology, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China 6.Xindian health center, SuiDe 718000, China #Equal contributors: Guo-Jie Wang, Le-Wei Yang and Shi-Rui Yang contributed equally to this work, as the same first author. Abstract: Objective: To compare three-dimensional (3D) volume measurement versus two-dimensional(2D) measurement during MR assessment of pre-treatment locally advanced cervical cancer, and toinvestigate the association of measurement outcomes with the staging of the tumor andhistopathological feature in locally advanced cervical cancer. Methods: 46patients were found having locally advanced cervical cancer that was confirmed by pathology (39squamous cell carcinoma,7 adenomatous carcinoma). All patients were scanned by conventional MR scan, DCE-MR, and DWI sequence. Measurement results were compared between normal tissues and cervicalcancer tissues in 3D and 2D. The association of measurement outcomes of 3D and 2D with thepathological grade and clinical stage of cervical cancer was explored. Results: There was no statisticallysignificant difference between the results of 3D volume measurements and 2D diameter measurements(P>0.05). A significant correlation was found between the 3D volume measurement and cervical cancerstages (P<0.05). There was no correlation between 2D measurements and the clinical stage of cervicalcancer (P>0.05). The outcomes between 3D volume measurement and 2D diameter measurement (Theshort cross-sectional diameter) among different histopathological grading of cervical cancerhad statistical significance (P<0.05). Conclusion:3D volume measurement is more effective compared with2D diameter measurement in MR assessment of locally advanced cervical cancer. In locally advancedcervical cancer, 3D volume measuring correlates with pathological grading and clinical stage. It providesmore accurate and comprehensive data on pre-treatment cervical cancer. Therefore, 3D volumemeasurement can be used in preoperative MR imaging to monitor response to therapy and improveradiomics features analysis in patients with locally advanced cervical cancer. Keywords: Cervical cancer, Locally advanced cancer, MR imaging, Tumor stage |