Volume 1, Issue.1, Pp13-18, 2018

STUDY ON TARGETING OF LUNG CANCERWITH POLYPEPTIDE RGD

Abstract: In this study, we aimed to study the selectivity of therapeutic targets incancer chemotherapy through a new targeting peptide. Peptide specifically bindingto human lung adenocarcinoma was identified through a NCI-H1299 subcutaneousxenograft model, results showed that RGD was concentrated mainly in the tumorwhile less accumulation of fluorescence in the tumor was found in control groupanimals. Ability of RGD to target human lung cancer tissue in vitro was investigatedthrough tissue microarray, results show that a 7-fold higher detection rate of[RGD]FITC was achieved compared with the control group, indicating the potentialof RGD as carriers for targeted cancer therapy drug. In conclusion, RGD isspecifically targeted to human lung adenocarcinoma xenografted and had highspecifically and affinity with lung cancer tissues, it might be an efficient method toincrease the selectivity of therapeutic targets in cancer chemotherapy.

Keywords: Lung Cancer, Polypeptide, arginine-glycine-aspartic acid.